11. I. Marin Jimenez
نویسندگان
چکیده
En esta revisión repasamos los estudios publicados hasta la fecha con las formulaciones orales y las preparaciones tópicas rectales de budesonida (Entocort y Budenofalk, en España Entocord e Intestifalk) para el tratamiento de la colitis ulcerosa. Este glucocorticosteroide de una elevada acción tópica y un importante metabolismo de primer paso hepático se ha utilizado en los últimos años como una formulación de liberación controlada, proporcionando resultados similares a la prednisolona pero sin suprimir de forma apreciable los niveles de cortisol plasmático. Aunque se han publicado muchos estudios sobre los efectos de la budesonida oral para el tratamiento de la enfermedad de Crohn, los estudios sobre esta misma forma galénica de administración de budesonida para el tratamiento de los pacientes con colitis ulcerosa son escasos. Después de revisar los trabajos publicados al respecto, se sugiere la necesidad de realizar un estudio controlado con las nuevas formulaciones de budesonida oral para el tratamiento de la colitis ulcerosa, con el objetivo de obtener pruebas sobre la eficacia real de este fármaco para el tratamiento de esta enfermedad.
منابع مشابه
Correction: Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study)
[This corrects the article DOI: 10.1371/journal.pone.0153096.].
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